![]() ![]() The nano liposomal spray exhibited sustained release with more than 5x increased bioavailability over standard tablets. The standard liposomal product was 3x more bioavailable than tablet. The chewable showed similar increase as nano liposomal, but a 5x higher dosage was used. (v) Liposome 1000ug - 14% - A liposome oral spray of B 12 with particle sizes of approximately 100 nm.(iv) Chewable 5000ug - 27% - A dissolvabletablet of B 12 that is absorbed through the sublingual mucosa.(iii) Tablet 1000ug - 5% - A standard tablet formulation of B 12 that is absorbed through the gastrointestinal tract.(ii) Emulsion 1000ug - 10% -An emulsion formulation of B 12 sublingual.(i) Nanocelle 1000ug -28% - A nano liposomal formulation of B 12 sublingual spray with an average particle size of about 20 nm.Route and Type of Formulation Administered Influences the Absorption and Disposition of Vitamin B 12 Levels in Serum This study compared five formulations for bioavailabilty in humans over 6 hours.A standard table (iii) was compared against an emulsion (ii), a chewabletablet (iv), an oral spray comprised of larger liposomes (v) and an oral spray comprised of very small (20 nanometer) liposomes. This means that Origine 8™ could be used as a once per day dose whilst standard green tea would require multiple doses of far greater size throughout the day to deliver the same levels of catechins achieved through a single dose of a far smaller size of Origine 8 TM. Origine 8™ resulted in a far greater half-life compared to the standard green tea extract.Ĭatechins delivered by Origine 8™ were still found to be present in the plasma after 24 hours whereas standard green tea was cleared from the body after only 6 hours. EGCG is regarded as a key catechin and Origine 8™ delivers a 10 fold greater total concentration. The average concentration of Epigallocatechin Gallate (EGCG) delivered by Origine 8™ was 6120 ng/ml compared to an average concentration of 612 ng/mlEGCG delivered by the standard green tea extract. Origine 8™ offered complete absorption of all 8 catechin found in green tea.With the exception of EGCG standard green tea extract provided insignificant levels of the other 7 catechin in comparison to Origine 8™ as demonstrated in figure 1. A 12 fold greater average concentration was delivered by Origine 8™. Origine 8™ delivered an average concentration of catechins of 11,630 ng/ml compared to a concentration of 930 ng/ml delivered by the standard green tea extract. The higher the bioavailability of an active substance, the more effect it has on the body.Ī study was conducted at the North-West University in South Africa, assessing the bioavailability of the green tea extract used in the production of Origine 8™ compared to a standard commercially available extract of green tea commonly found in green tea supplements. This increased circulation time of key nutrients in the bloodstream significantly improves bioavailability. Liposomal delivery offers a targeted and complete absorption of active ingredients with a delayed‑release effect, unlike all other nutrient delivery methods. ![]() The majority is excreted unused via the intestines or kidneys. However, due to the low absorption and bioavailability rates of traditional oral capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract or are simply not absorbed in the small intestine at all. The aim of taking any supplement is to ensure its transport into the bloodstream. ⑴ This allows for the ingredients to be absorbed and utilized rather than being destroyed in the stomach. Liposomes are a revolutionary way of encapsulating active ingredients in a phospholipid “bubble” to protect and deliver them directly to the cells of your tissues, which are reached via the bloodstream. ![]()
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